Top things to know about conception
It's much more complicated than “sperm meets egg”
Only a tiny fraction of the sperm that entered the vagina make it to the fallopian tube
It takes about 6-12 days for the fertilized egg to travel to the uterus and attach to the uterus in a process known as implantation
This is what most of us learn about how a pregnancy happens:
Sperm meets egg, egg meets uterus, and boom: pregnancy.
While that is the bare bones of how conception works, there’s a lot going on in a person’s body that helps—or sometimes hinders—conception.
Here, we’ll talk through what different parts of the body are doing at different times to prepare for pregnancy when it occurs from penis-vagina sex or from other forms of insemination, such as artificial insemination. Some of this information might also apply to conception that happens with the help of artificial reproductive technologies like in-vitro fertilization (IVF), though we don't directly focus on that topic here.
Also, FYI, a lot of this information is based on animal research, especially events that happen deep in the reproductive tract. It’s possible some of this information will change in the future.
How ovulation works
Before diving into conception, you should brush up on your knowledge of , and of how ovulation works. Ovulation is when an egg is released from the ovary, and is critical to the whole process.
We pick up where ovulation ends.
How the cervix and vagina prepare for pregnancy
The cervix is what connects the vagina to the uterine cavity. It has glands that produce cervical fluid (also called cervical mucus), which passes through the vagina. You sometimes might see cervical fluid on your underwear or on toilet paper as you wipe.
Cervical fluid characteristics change throughout the menstrual cycle (1-3):
During and just after your period: You may not notice any cervical fluid.
Between your period and ovulation: As estrogen levels rise, the amount of cervical fluid increases and becomes wetter, thicker and cloudier (2,3).
Around ovulation: Cervical fluid often looks like egg white: it’s thin, slippery, and stretchy (2-4).
So why does this matter? In short, sperm swim best through wet and stretchy cervical mucus (3,4). If this fluid is absent or is thick and sticky, sperm have a hard time passing the cervix (3,4).
The time period between when cervical fluid is ideal for sperm and ovulation is known as the fertile window.
In the instance of sexual interactions, sperm have an effect on the vagina. Normally the vagina is somewhat acidic, in order to protect against infection (5). When exposed to sperm, the vagina becomes less acidic (1,5).
How the uterus prepares for pregnancy
During your period, the uterus sheds the endometrium, which built up during the previous menstrual cycle. After shedding, the endometrium waits for estrogen (produced in the ovaries) to rise. Estrogen causes the lining of the uterus to thicken by stimulating the endometrial cells to divide (2).
After ovulation, the endometrium prepares for the possible arrival of a fertilized egg. In response to increasing levels of progesterone:
Endometrial cells stop dividing and start growing larger
The number of arteries increases
Uterine contractions are suppressed (2).
Also, the rise in progesterone after ovulation also signals to the endometrium to release little sugar-filled sacs into the uterus to nourish the incoming egg (2).
What does sperm do?
If a person has unprotected penis-vagina sex during their fertile window, probably at least some sperm will make it’s way through the cervix and into the uterus. (With artificial insemination, sperm is often introduced directly into the cervix or uterus, so this step is bypassed.)
Although sperm use their tails to swim through cervical mucus in the vagina and cervix, it’s actually the uterus that moves sperm through it and into the fallopian tubes (1).
Sexual activity can cause the brain to release the hormone oxytocin (1,6), which causes the innermost layer of the uterus to contract and push the sperm onwards (1,5,6). The uterus also has little finger like structures called cilia that help move the sperm, hopefully, towards the egg (1).
How the uterus interacts with sperm
Sperm triggers an immune response when it enters the uterus (5). Once sperm enter, the number of white blood cells increases, and they begin to attack the dying sperm, though it’s possible they may also attack healthy sperm too (1,5).
Also, sperm may end up going up the wrong fallopian tube. The vast majority of the time, a person only releases one egg from one ovary. That means that only one of the two fallopian tubes will have eggs, and some sperm will have gotten it wrong.
Only a tiny fraction of the sperm that entered the vagina make it to the fallopian tube (5).
How does fertilization work?
After sperm arrive, the magic happens in the fallopian tubes. As the fallopian tube pushes the egg towards the uterus, cilia push the sperm towards the egg. Progesterone and estrogen influence this process by increasing the number of cilia and how fast they move (1).
The egg and surrounding cells produce a chemical that attracts sperm (1,7). Sperm may be attracted to the temperature at the ovarian-end of the fallopian tube, which tends to be warmer (1,5).
As they travel through the fallopian tubes, sperm gain the ability to fertilize an egg (1). They undergo two processes: capacitation, where its outer layer is changed, and hyperactivation, which changes the way the sperm’s tail moves (1,5).
Although it’s come so far and has already changed, the sperm still has work to do: specifically, breaking through the barriers around the egg.
How does sperm enter the egg?
It needs to do two things:
Break through a group of cells known as the cumulus oophorus that surround the egg. The sperm dissolves these cells using an enzyme (1,7).
Break through the outer membrane of the egg. The sperm essentially fuses to and digests this membrane using an enzyme (1,7). Once a sperm has penetrated an egg, this membrane changes, and becomes impenetrable to other sperm (1,7).
Now attached, the sperm’s nucleus—where the chromosomes are stored—enters the egg cell looking for the egg’s nucleus (1). Once it meets the egg, the nuclei from the egg and sperm merge and share their genetic material (1,7).
If all goes well, a fertilized egg becomes a zygote (1,7). The egg now contains all the genetic material it will need to become a person.
Implantation: what happens after the egg is fertilized
It takes about 6-12 days for the fertilized egg to travel to the uterus and attach to the uterus in a process known as implantation (1,8). The egg is pushed back towards the uterus by the cilia (1). The egg must attach to the uterus to become a viable pregnancy.
While traveling to the uterus, the egg has been dividing and forming a few different structures (7).
Once it’s big enough *and* in the uterus, the egg transitions from being known as a zygote to being called a blastocyst (1).
When does a pregnancy officially begin?
When the uterus detects the blastocyst, it releases enzymes to break down the blastocyst’s outer membrane. Once that barrier is broken down, the blastocyst can attach to the endometrium (1). This is when a pregnancy officially begins.
It’s a complicated process
However, sometimes a fertilized egg doesn't make it to implantation.
For every 10 fertilized eggs, between 4 and 6 won’t make it to implantation (9,10).
These losses generally aren't considered miscarriages, as most healthcare professionals consider a pregnancy to have begun at implantation. However, people who think or know they lost a fertilized egg (such as people using artificial reproductive technologies) may consider this to be akin to a more traditional miscarriage.
As you can see, there’s a lot of steps in this process, and if any of them don’t go exactly right, pregnancy may not occur. Sometimes, the egg attaches somewhere else, like to the fallopian tube, and the pregnancy will not be viable. This is called an ectopic pregnancy and should be treated as a medical emergency.
Although it can be complicated, it's pretty amazing how often our bodies do get it right.
Article originally published 29 June 2019.